GOOD NEWS : UPDATE STUDY on PrEP and Bone Density issue .New stop Truvada use in healthy bodies and i use condoms

GOOD NEWS A new scientific trial of truvada use in the PrEP protocol is now been published, The study, we read about it in BETA,   looks at the problem of bone density reduction in young people 25 and under who were in a control study. It reports that  when trucada use is discontinued,  the body, with no other serious health issues,  will revert over time to normal bone density As to how long to return to normal age makes the difference. This is good news. And I believe supports my call for a continuation of funding for SAFE SEX and CONDOM use, Please read and share. Another step in informing a person about all the issues they need to know in deciding yes or no to PrEP. 

here is the report we found in BETA:

PrEP Does Not Appear to Cause Permanent Bone Loss

February 23, 2016, by Emily Newman

BETA is reporting from the 2016 Conference on Retroviruses and Opportunistic Infections (CROI) this week in Boston—bringing you the latest news, updates, and research on HIV treatment and prevention.

One of the drugs contained in PrEP drug Truvada, tenofovir disoproxil fumarate (TDF), has been associated with small decreases in bone mineral density. Researchers have raised concerns that PrEP use may prevent peak bone mass formation and increase risk of fractures. At CROI today, results were presented of a study demonstrating that bone mineral density returns to normal levels after people stopped taking PrEP. The implications of this study may be important for providers who counsel clients about the benefits and risks of starting and stopping PrEP.

Dr. Robert Grant (photo: Liz Highleyman)

“Recovery of BMD [bone mineral density] after stopping PrEP has not been fully evaluated,” said Robert M. Grant, MD, the lead investigator of the study of the Gladstone Institutes, the University of California San Francisco and San Francisco AIDS Foundation. “Bone mineral density appears to be a dynamic and regulated process that does return to placebo levels after stopping PrEP.”

The bone mineral density study was conducted with a subset of participants who participated in the oral PrEP iPrEx randomized controlled trial and open-label extension. A total of 498 men and transgender women received bone mineral density scans (DXA scans) of the spine and hip at the iPrEx baseline visit, every 24 weeks during the study, and when they enrolled in the open-label extension portion of the iPrEx trial. The median age of participants was 25 years and 11% identified as transgender.

Among people assigned to take active drug during the randomized controlled portion of the study, the average hip and spine bone mineral density decreased from the time study drug was begun. (Analyses were focused on people in the study who achieved drug levels corresponding to taking at least 2 to 3 tablets of study drug per week.)

“You can see that changes in bone mineral density occurred in both the hip and the spine. They occurred by week 24 and there was no substantial decrement after week 24,” said Grant.

After drug was stopped, and before participants enrolled into the open-label extension portion of the study, bone mineral density in both the hip and the spine increased. People under age 25 experienced a faster return to normal levels than people over age 25.

People under age 25 recovered bone mineral density of the hip and spine by six months after stopping drug. People older than 25 recovered bone mineral density completely in the spine within six months, and completely in the hip by the start of the open-label extension. (The median time between the randomized controlled study and the open-label extension was 1.5 years.)

It is not yet known how a second exposure to PrEP (as in, for example, the open-label extension portion of the iPrEx study) affects bone mineral density. Grant reported that participants in the iPrEx open-label extension did receive DXA scans every 24 weeks, and his team plans to present those results later this year.

Bone loss and gain in hip by age (Photo: BETA)

Bone loss and gain in spine by age (Photo: BETA)

 Source:

Grant, R. and others. Abstract 48LB. Recovery of bone mineral density after stopping oral HIV preexposure prophylaxis. CROI 2016.

SPROUT : The Little Pink Pull ..viagra for women???? As the song said "GO ASK ALICE ..... FEED HER....

PHARMA scores a new $$$$$$$$$$$ victory at FDA .. the female VIAGRA called SPROUT …. WITH ONE HUGE WINDFALL difference: While the expensive blue pill for men SHOULD BE TAKEN BEFORE engaging in sexual activity, WOMEN ARE TO TAKE THE PINK PILL DAILY and the use is not tied to specific sexual activity. Now add that to the little blue pill called TRUVADA for sexually active women and men to protect themselves from possible transmission of HIV in condom-less vaginal or anal intercourse(big subway campaign in NYC sponsored by the NYC Health Department that promotes condom-less sex by implication). We see the further chemicalization of of the sex life of an individual who wishes to be sexually active. No mention in announcement of the possible serious side effects or the interaction with other medications including the widely prescribed anti-depression/anxiety drugs. Or the shedding of the chemicals in the body fluids of the people engaged in sexual activity.

Wild as this next statement may sound I am still going to suggest that there is a darker Big Brother aspect: the policy to keep people in a constant state of sexual arousal to keep then distracted from the economic reality of their lives reminds me of what happened in NYC right after the STONEWALL REBELLION. There were well know cruising areas along the waterfront in the far West Village and the lower West Side that the police department would selectively police. The cops, usually at the request of the owners of the those piers that had not been abandoned and by the owners of the trucking services that legally parked on the West Side waterfront, patrolled the area. For gay men it was a dance of hide and seek. The police no longer policed these areas because of a tacit agreement between the cities policy leaders in response to the political demands, of principally the Gay Activist Alliance and later a small group of activist in SEX PANIC, of a hands-off and out of the gay cruising areas demand. The results were the trucks and Piers at night became more dangerous with pickpockets, rapists and assault because the police no longer were patrolling. While the demands of these activists addressed police harassment of homosexuals looking for sex, I believe there was another politician goal. Keep them is a constant state of sexual stimulation and tumescence and they will stop their police and politician confrontations on other issues that impacted the lives of lesbians and gay men.

So here we are again in 2015 : the good goal a having a healthy sexual life for men and women suffering from mental of physical distention is exploited to keep people quiet .. now please reread and think about the consequences of what the police policy did in the gay male community in the 70's and what one of the potential side effects of SPROUT can be. Women will once again be pressured not to say no ...just like happened when the “pill” was introduced to women in the 60's Sprout really benefits men as it makes their sexual demands ..chemically initiated... on women medically possible. What SROUT shares with the rape drug if any I will await what women have to say. As to the name ..Oh please it sees to be rooted in the biology of women and conception …. despite the fact that the statistics point to older women and sexual function.

So caution is in order with SPROUT as it was with the PILL and the introduction of VIAGRA.

FDA approves 'female Viagra' pill Flibanserin after two rejections

Drug to help women boost sex drive overcomes concerns over effectiveness and side effects, but some experts fear precedent campaigning could set

THEGUARDIAN.COM|BY JANA KASPERKEVIC